Ectopic overexpression of F681Y mutant almost completely rescued WIF1 reporter activity and partially rescued WIF1 protein levels while H3K27me3 levels were completely attenuated (Fig. overexpression of EZH2 attenuated WIF1-reporter activity.
ROCK inhibitors
Ectopic overexpression of F681Y mutant almost completely rescued WIF1 reporter activity and partially rescued WIF1 protein levels while H3K27me3 levels were completely attenuated (Fig. overexpression of EZH2 attenuated WIF1-reporter activity.