Based on these results, we conclude the BPII region of Claspin plays an important role in the binding of Claspin to branched, replication fork-like DNA structures. Open in a separate
Consistent with this idea, immunoprecipitation of GFP-CtIPC from cells also expressing full-length FLAG-CtIP revealed that the two proteins did indeed interact (Number 5F, lane 1). truncation. The 2 2 base-pair