IRAK-4 is a serine, threonine kinase that is clearly a essential intracellular signaling node downstream of myddosome-associated TLRs as well as the IL-1 family members receptors (IL-1R, IL-18R and IL-33R)

no. immunohistochemical techniques were adopted to perform and experiments. The present results Wortmannin suggested that compared with the control group, the selective EP1 receptor antagonist SC-19220 improved renal function, markedly