Using the same cohort, we’ve previously demonstrated which the upregulation of Akt activation is normally significantly connected with reduced survival, and for that reason PTEN loss is normally one possible

Immunophenotypic characterization of these mice was performed by conducting confocal analysis of brain sections, stained with antibodies specific for the pan-OL lineage marker OLIG2, for OPC-specific surface receptor (e.g., platelet-derived